Title : pVHL-mediated SMAD3 degradation suppresses TGF-β signaling.

Pub. Date : 2022 Jan 3

PMID : 34860252






1 Functional Relationships(s)
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1 We show that pVHL directly interacts with conserved lysine and proline residues in the MH2 domain of SMAD3, triggering degradation. Proline von Hippel-Lindau tumor suppressor Homo sapiens