Title : The unique Akt inhibitor SC66 suppressed AMPK activity and abolished autophagy through the EGFR-p62 pathway.

Pub. Date : 2022 Feb

PMID : 34854518






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1 In the present study, we found that SC66, a pyridine-based allosteric Akt inhibitor, suppressed basal and H2 O2 -induced autophagy concurrent with decreased phosphorylation and activity of AMPK. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens