Title : Tubule-specific deletion of LincRNA-p21ameliorates lipotoxic kidney injury.

Pub. Date : 2021 Dec 3

PMID : 34853727






1 Functional Relationships(s)
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1 Mechanistically, HFD- or PA-initiated lipotoxicity suppressed the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR)/murine double minute 2 homolog (MDM2) signaling cascade to activate p53 and enhance the transcriptional activity of LincRNA-p21. Palmitic Acid thymoma viral proto-oncogene 1 Mus musculus