Title : Simvastatin potentiates the cell-killing activity of imatinib in imatinib-resistant chronic myeloid leukemia cells mainly through PI3K/AKT pathway attenuation and Myc downregulation.

Pub. Date : 2021 Dec 15

PMID : 34843676






2 Functional Relationships(s)
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1 Simvastatin potentiates the cell-killing activity of imatinib in imatinib-resistant chronic myeloid leukemia cells mainly through PI3K/AKT pathway attenuation and Myc downregulation. Simvastatin AKT serine/threonine kinase 1 Homo sapiens
2 Mechanistically, the cooperative interaction of simvastatin and imatinib was associated with the inactivation of the PI3K/Akt signaling pathway, which was a classical downstream pro-survival cascade of the BCR-ABL kinase. Simvastatin AKT serine/threonine kinase 1 Homo sapiens