Title : Quinone binding in respiratory complex I: Going through the eye of a needle. The squeeze-in mechanism of passing the narrow entrance of the quinone site.

Pub. Date : 2022 Jan

PMID : 34813075






2 Functional Relationships(s)
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1 The narrow entrance of the quinone chamber located in ND1 subunit forms a bottleneck (eye of a needle) which in all resolved structures was shown to be too small for a bulky quinone to pass through, and it was suggested that a conformational change is required to open the channel. quinone mitochondrially encoded NADH dehydrogenase 1 Homo sapiens
2 The narrow entrance of the quinone chamber located in ND1 subunit forms a bottleneck (eye of a needle) which in all resolved structures was shown to be too small for a bulky quinone to pass through, and it was suggested that a conformational change is required to open the channel. quinone mitochondrially encoded NADH dehydrogenase 1 Homo sapiens