Title : Renin-Angiotensin-Aldosterone System Inhibitors Prevent the Onset of Oxaliplatin-Induced Peripheral Neuropathy: A Retrospective Multicenter Study and in Vitro Evaluation.

Pub. Date : 2022 Feb 1

PMID : 34803077






2 Functional Relationships(s)
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1 Moreover, 1 muM SCH772984 (a selective inhibitor of extracellular signal-regulated kinase, ERK1/2) and 500 muM SQ22536 (a cell-permeable adenylate cyclase (AC) inhibitor) markedly abolished neuroprotective effects of candesartan and enalapril. candesartan mitogen activated protein kinase 3 Rattus norvegicus
2 These results indicate that RAASIs possess preventive or therapeutic effects in acute and chronic OIPN, candesartan and enalapril may directly increase in the activity of ERK1/2 and AC in PC12 cells. candesartan mitogen activated protein kinase 3 Rattus norvegicus