Pub. Date : 2021 Nov
PMID : 34799701
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methionine synthase is essential for cancer cell proliferation in physiological folate environments. | Folic Acid | 5-methyltetrahydrofolate-homocysteine methyltransferase | Homo sapiens |
| 2 | We find that the enzyme that couples folate and methionine metabolic cycles, methionine synthase, is required for cancer cell proliferation and tumour growth when 5-methyl tetrahydrofolate (THF), the major folate found in circulation, is the extracellular folate source. | Folic Acid | 5-methyltetrahydrofolate-homocysteine methyltransferase | Homo sapiens |
| 3 | We find that the enzyme that couples folate and methionine metabolic cycles, methionine synthase, is required for cancer cell proliferation and tumour growth when 5-methyl tetrahydrofolate (THF), the major folate found in circulation, is the extracellular folate source. | Folic Acid | 5-methyltetrahydrofolate-homocysteine methyltransferase | Homo sapiens |
| 4 | We find that the enzyme that couples folate and methionine metabolic cycles, methionine synthase, is required for cancer cell proliferation and tumour growth when 5-methyl tetrahydrofolate (THF), the major folate found in circulation, is the extracellular folate source. | Folic Acid | 5-methyltetrahydrofolate-homocysteine methyltransferase | Homo sapiens |
| 5 | In such physiological conditions, methionine synthase incorporates 5-methyl THF into the folate cycle to maintain intracellular levels of the folates needed for nucleotide production. | Folic Acid | 5-methyltetrahydrofolate-homocysteine methyltransferase | Homo sapiens |
| 6 | In such physiological conditions, methionine synthase incorporates 5-methyl THF into the folate cycle to maintain intracellular levels of the folates needed for nucleotide production. | Folic Acid | 5-methyltetrahydrofolate-homocysteine methyltransferase | Homo sapiens |