Pub. Date : 2021 Nov 18
PMID : 34795217
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | With RNAi knockdown and CRISPR/Cas9 knockout models, we further clarified the mechanisms by which NF1 loss reactivates the PI3K/AKT and MAPK/ERK signaling pathways, while DUSP9 loss activates the MAPK/ERK signaling pathways, thereby inactivating FOXO3, followed by degradation of FOXO3, finally induced lenvatinib resistance. | lenvatinib | mitogen-activated protein kinase 1 | Mus musculus |