Title : Sensitive ratiometric fluorescence probe based on chitosan carbon dots and calcein for Alkaline phosphatase detection and bioimaging in cancer cells.

Pub. Date : 2021 Dec 15

PMID : 34794579






3 Functional Relationships(s)
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1 In this study, we describe the development of a reliable and novel fluorescent assay for ALP detection based on chitosan carbon dots (C-CDs, peak emission, 412 nm) and calcein (peak emission, 512 nm). fluorexon alkaline phosphatase, placental Homo sapiens
2 Utilizing the ALP-triggered generation of phosphate ions (PO43-) from the substrate p-nitrophenyl phosphate (pNPP), the Eu3+ ions bind PO43- (which shows a higher affinity toward Eu3+ than calcein), and the fluorescence of calcein is recovered. fluorexon alkaline phosphatase, placental Homo sapiens
3 Utilizing the ALP-triggered generation of phosphate ions (PO43-) from the substrate p-nitrophenyl phosphate (pNPP), the Eu3+ ions bind PO43- (which shows a higher affinity toward Eu3+ than calcein), and the fluorescence of calcein is recovered. fluorexon alkaline phosphatase, placental Homo sapiens