Title : Cinnamophilin overcomes cancer multi-drug resistance via allosterically modulating human P-glycoprotein on both drug binding sites and ATPase binding sites.

Pub. Date : 2021 Dec

PMID : 34794239






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cinnamophilin uncompetitively inhibited the efflux of doxorubicin and rhodamine 123 and exhibited a distinct binding behavior compared with verapamil, the P-gp standard inhibitor. Verapamil ATP binding cassette subfamily B member 1 Homo sapiens
2 In regard to P-gp energy consumption, verapamil-stimulated ATPase activity was further enhanced by cinnamophilin at concentrations of 0.1, 1, 10, and 20 muM. Verapamil ATP binding cassette subfamily B member 1 Homo sapiens