Title : Prediction of cytochromes P450 3A and 2C19 modulation by both inflammation and drug interactions using physiologically based pharmacokinetics.

Pub. Date : 2022 Jan

PMID : 34791831






3 Functional Relationships(s)
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1 The aim of our study was to develop a physiologically based pharmacokinetic (PBPK) model to foresee the impact of elevated IL-6 levels in combination with drug interactions with esomeprazole on CYP3A and CYP2C19. Esomeprazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 The impact of IL-6 and esomeprazole on the exposure to CYP3A and CYP2C19 probe substrates and respective metabolites were correctly predicted. Esomeprazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 The impact of IL-6 and esomeprazole on CYP3A and CYP2C19 activities after a hip surgery were correctly predicted with the developed PBPK models. Esomeprazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens