Title : PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia.

Pub. Date : 2022 Mar 3

PMID : 34788382






1 Functional Relationships(s)
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1 Using a novel pharmacological agent OSU-2S in parallel with genetic approaches, we discovered that PP2A enforces c-Myc and p21 dependent terminal differentiation, proliferation arrest and apoptosis in AML. osu protein phosphatase 2 phosphatase activator Homo sapiens