Pub. Date : 2021 Nov 25
PMID : 34787621
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Potential interference of graphene nanosheets in immune response via disrupting the recognition of HLA-presented KK10 by TCR: a molecular dynamics simulation study. | Graphite | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |
| 2 | For the illustrated human immunodeficiency virus (HIV) antigen peptide KK10, human leukocyte antigen (HLA), and T cell receptor (TCR) ternary complex, we found that the graphene nanosheet could disrupt the critical protein-protein interactions between TCR and peptide-HLA and impair the antigen recognition by TCR, leaving the antigen presentation unaffected. | Graphite | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |
| 3 | For the illustrated human immunodeficiency virus (HIV) antigen peptide KK10, human leukocyte antigen (HLA), and T cell receptor (TCR) ternary complex, we found that the graphene nanosheet could disrupt the critical protein-protein interactions between TCR and peptide-HLA and impair the antigen recognition by TCR, leaving the antigen presentation unaffected. | Graphite | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |
| 4 | For the illustrated human immunodeficiency virus (HIV) antigen peptide KK10, human leukocyte antigen (HLA), and T cell receptor (TCR) ternary complex, we found that the graphene nanosheet could disrupt the critical protein-protein interactions between TCR and peptide-HLA and impair the antigen recognition by TCR, leaving the antigen presentation unaffected. | Graphite | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |
| 5 | For the illustrated human immunodeficiency virus (HIV) antigen peptide KK10, human leukocyte antigen (HLA), and T cell receptor (TCR) ternary complex, we found that the graphene nanosheet could disrupt the critical protein-protein interactions between TCR and peptide-HLA and impair the antigen recognition by TCR, leaving the antigen presentation unaffected. | Graphite | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |
| 6 | Moreover, the hydrophobic interaction and van der Waals potential energy collectively drive the spontaneous separation of TCR from the peptide-HLA complex by graphene nanosheets. | Graphite | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |