Title : SARS-CoV-2 spike evolutionary behaviors; simulation of N501Y mutation outcomes in terms of immunogenicity and structural characteristic.

Pub. Date : 2022 Feb

PMID : 34783057






1 Functional Relationships(s)
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1 Surprisingly, we discovered that this mutation reduces the immunogenicity of the spike protein; also, displacement of Asn with Tyr reduces protein compactness and significantly increases the stability of the spike protein and its affinity to ACE2. Tyrosine angiotensin converting enzyme 2 Homo sapiens