Pub. Date : 2022 Apr
PMID : 34783022
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we evaluated whether the inhibition of class I HDACs can attenuate angiotensin II (ANG II)-induced fibrogenesis and mitochondrial malfunction through its effects on reactive oxygen species (ROS) and calcium dysregulation in human cardiac fibroblasts (CFs). | Calcium | angiotensinogen | Homo sapiens |
| 2 | In this study, we evaluated whether the inhibition of class I HDACs can attenuate angiotensin II (ANG II)-induced fibrogenesis and mitochondrial malfunction through its effects on reactive oxygen species (ROS) and calcium dysregulation in human cardiac fibroblasts (CFs). | Calcium | angiotensinogen | Homo sapiens |
| 3 | ANG II activated CFs by increasing mitochondrial calcium content and ATP production, which may be caused by increased HDAC activity. | Calcium | angiotensinogen | Homo sapiens |
| 4 | Inhibition of HDAC1 attenuated the effects of ANG II by reducing mitochondrial ROS generation and calcium overload. | Calcium | angiotensinogen | Homo sapiens |