Title : Human carboxylesterase 1A plays a predominant role in the hydrolytic activation of remdesivir in humans.

Pub. Date : 2022 Jan 5

PMID : 34774545






1 Functional Relationships(s)
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1 Chemical inhibition and reaction phenotyping assays suggested that human carboxylesterase 1 (hCES1A) played a predominant role in remdesivir hydrolysis, while cathepsin A (CTSA), acetylcholinesterase (AchE) and butyrylcholinesterase (BchE) contributed to a lesser extent. remdesivir carboxylesterase 1 Homo sapiens