Pub. Date : 2021 Oct 30
PMID : 34771624
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Through a systematic validation of the detected interactions by co-immunoprecipitation and Western blot, followed by the biochemical and functional characterization of the contribution of each interactor to NIS PM residency and iodide uptake, we were able to identify a pathway by which the PM localization and function of NIS depends on its binding to SRC kinase, which leads to the recruitment and activation of the small GTPase RAC1. | Iodides | solute carrier family 5 member 5 | Homo sapiens |