Title : Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARγ activation-dependent manner.

Pub. Date : 2022 Feb

PMID : 34748921






3 Functional Relationships(s)
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1 Dietary supplementation of TB significantly increased skin temperature of the inguinal region in mice and induced the expression of UCP1 protein. Theobromine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus
2 Furthermore, in mouse-derived primary adipocytes, TB upregulated the expression of the UCP1 protein and mitochondrial mass in a PPARgamma ligand-dependent manner. Theobromine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus
3 These results indicate that dietary supplementation of TB induces browning in subcutaneous WAT and enhances PPARgamma-induced UCP1 expression in vitro, suggesting its potential to treat obesity. Theobromine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus