Title : A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN.

Pub. Date : 2021 Nov 17

PMID : 34748320






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using heteromultivalent liposomes copresenting mannosides bearing aromatic aglycones with natural glycan ligands, we serendipitously discovered striking cooperativity effects for DC-SIGN+ but not for Langerin+ cell lines. Polysaccharides CD209 molecule Homo sapiens
2 We further present preliminary evidence that the aglycone allosterically activates glycan recognition and thereby contributes to DC-SIGN-specific cell targeting. Polysaccharides CD209 molecule Homo sapiens