Pub. Date : 2021 Nov 2
PMID : 34725737
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | How does nintedanib overcome cancer drug-resistant mutation of RET protein-tyrosine kinase: insights from molecular dynamics simulations. | nintedanib | ret proto-oncogene | Homo sapiens |
| 2 | Nintedanib can effectively inhibit the RET L881V mutant, whereas its analog compound 1 is unable to combat this mutant. | nintedanib | ret proto-oncogene | Homo sapiens |
| 3 | Here, molecular dynamics (MD) simulations, binding free energy calculations, and structural analysis were performed to uncover the mechanism of overcoming the resistance of RET L881V mutant to nintedanib. | nintedanib | ret proto-oncogene | Homo sapiens |