Title : Inhibition of the cysteinyl leukotriene pathways increases survival of RGCs and reduces microglial activation in ocular hypertension.

Pub. Date : 2021 Dec

PMID : 34715090






2 Functional Relationships(s)
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1 Therefore, we tested the leukotriene receptors CysLT1R/GPR17-selective antagonist Montelukast (MTK) for its efficacy to modulate the reactive state of microglia in order to ameliorate RGCs loss in experimental glaucoma. montelukast G protein-coupled receptor 17 Rattus norvegicus
2 In the ON, OHT induction increased the number of GPR17+ cells, showing a significant reduction following MTK treatment. montelukast G protein-coupled receptor 17 Rattus norvegicus