Title : In-vitro characterization of coding variants with predicted functional implications in the efflux transporter multidrug resistance protein 4 (MRP4, ABCC4).

Pub. Date : 2022 Apr 1

PMID : 34693929






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 V458M, a novel variant not previously studied, and T1142M, showed reduced activity compared to MRP4 wildtype for E217betaG and TCA (P < 0.01), while L18I, G187W, K293E, and R531Q moderately increased activity in a substrate-dependent manner. Taurocholic Acid ATP binding cassette subfamily C member 4 Homo sapiens