Title : Mechanistic roles of tyrosine phosphorylation in reversible amyloids, autoinhibition, and endosomal membrane association of ALIX.

Pub. Date : 2021 Nov

PMID : 34688656






1 Functional Relationships(s)
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1 As evidenced by transmission electron microscopy and fluorescence and CD spectroscopy, the proline-rich domain (PRD) of ALIX, which encodes binding epitopes of multiple cellular partners, formed rope-like beta-sheet-rich reversible amyloid fibrils that dissolved upon Src-mediated phosphorylation and were restored on PTP1B-mediated dephosphorylation of its conserved tyrosine residues. Proline programmed cell death 6 interacting protein Homo sapiens