Title : Chronic cadmium exposure induces epithelial mesenchymal transition in prostate cancer cells through a TGF-β-independent, endoplasmic reticulum stress induced pathway.

Pub. Date : 2021 Dec 15

PMID : 34687772






1 Functional Relationships(s)
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1 Removal of ROS by N-acetylcysteine significantly reduced ER stress in prostate cancer cells, followed by the decrease of Smad3 phosphorylation and expression of nuclear Snail, resulting in the inhibition of EMT and malignant phenotypic changes of prostate cancer cells. Reactive Oxygen Species SMAD family member 3 Homo sapiens