Title : Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4+ T cells.

Pub. Date : 2022 Mar

PMID : 34687147






1 Functional Relationships(s)
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1 In functional assays, pretreatment of EC with simvastatin to inhibit mevalonate metabolism resulted in a dose-dependent reduction in the costimulation of CD45RO+ CD4+ T cell proliferation as well as IL-2, IFNgamma and IL-6 production vs. vehicle-treated EC. Simvastatin interleukin 6 Homo sapiens