Pub. Date : 2021 Oct 14
PMID : 34681744
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The additional administration of pioglitazone significantly increased circulating adiponectin levels and significantly reduced media thickness at 4 and 12 weeks, respectively (p = 0.0002 and p = 0.0107, respectively). | Pioglitazone | adiponectin, C1Q and collagen domain containing | Rattus norvegicus |
| 2 | CONCLUSIONS: Under diabetic conditions, pioglitazone leads to elevated circulating levels of adiponectin and to an inhibition of bioprosthetic graft degeneration, including lower expression of chondro-osteogenic genes, decreased media proliferation, and inhibited graft calcification in a small-animal model of DM. | Pioglitazone | adiponectin, C1Q and collagen domain containing | Rattus norvegicus |