Title : Rescuing effect of folates on methotrexate cytotoxicity in human trophoblast cells.

Pub. Date : 2021 Oct 19

PMID : 34665710






5 Functional Relationships(s)
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1 OBJECTIVES: Methotrexate (MTX)is a folate antagonist that is administered in several conditions such as rheumatoid arthritis. Folic Acid metaxin 1 Homo sapiens
2 Although MTX side effects could be decreased by folate supplementation, the current guideline on folate administration is not precisely established, which could result in irreversible damage especially in high-risk groups like women in childbearing-age. Folic Acid metaxin 1 Homo sapiens
3 Although MTX side effects could be decreased by folate supplementation, the current guideline on folate administration is not precisely established, which could result in irreversible damage especially in high-risk groups like women in childbearing-age. Folic Acid metaxin 1 Homo sapiens
4 Thus, this study aimed to investigate the in vitro rescuing effect of different folates including folic acid (FA), 5-methyltetrahydrofolate (MTHF) and folinic acid (5-Formyltetrahydrofolic acid, FTHF) on MTX-treated trophoblast cells. Folic Acid metaxin 1 Homo sapiens
5 Thus, this study aimed to investigate the in vitro rescuing effect of different folates including folic acid (FA), 5-methyltetrahydrofolate (MTHF) and folinic acid (5-Formyltetrahydrofolic acid, FTHF) on MTX-treated trophoblast cells. Folic Acid metaxin 1 Homo sapiens