Title : The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress.

Pub. Date : 2021 Oct

PMID : 34663976






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In the nucleus, the altered PHGDH activity restricts NAD+ level and compartmentally repressed NAD+-dependent PARP1 activity for poly(ADP-ribosyl)ation of c-Jun, thereby leading to impaired c-Jun transcriptional activity linked to cell growth inhibition. poly(adp-ribosyl) poly(ADP-ribose) polymerase 1 Homo sapiens