Pub. Date : 2021
PMID : 34659899
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We demonstrate that asciminib synergizes with ponatinib in inducing growth-arrest and apoptosis in patient-derived CML cell lines and murine Ba/F3 cells harboring BCR-ABL1 T315I or T315I-including compound mutations. | ponatinib | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 2 | Asciminib and ponatinib also produced cooperative effects on CRKL phosphorylation in BCR-ABL1-transformed cells. | ponatinib | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |
| 3 | The growth-inhibitory effects of the drug combination "asciminib+ponatinib" was further enhanced by hydroxyurea (HU), a drug which has lately been described to suppresses the proliferation of BCR-ABL1 T315I+ CML cells. | ponatinib | c-abl oncogene 1, non-receptor tyrosine kinase | Mus musculus |