Title : Lactate in the tumour microenvironment: From immune modulation to therapy.

Pub. Date : 2021 Nov

PMID : 34656878






2 Functional Relationships(s)
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Protein Name
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1 Excessive lactate secreted by metabolism-reprogrammed cancer cells regulates immune responses via causing extracellular acidification, acting as an energy source by shuttling between different cell populations, and inhibiting the mechanistic (previously "mammalian") target of rapamycin (mTOR) pathway in immune cells. Lactic Acid mechanistic target of rapamycin kinase Homo sapiens
2 Excessive lactate secreted by metabolism-reprogrammed cancer cells regulates immune responses via causing extracellular acidification, acting as an energy source by shuttling between different cell populations, and inhibiting the mechanistic (previously "mammalian") target of rapamycin (mTOR) pathway in immune cells. Lactic Acid mechanistic target of rapamycin kinase Homo sapiens