Title : Peripheral Hybrid CB1R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis.

Pub. Date : 2021

PMID : 34650521






2 Functional Relationships(s)
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1 However, the skin level of MRI-1867, an MDR1 substrate, was dramatically lower in B6 mice (0.023 microM) than in Mdr1a/b-Bcrp KO mice (8.8 microM) due to a bleomycin-induced increase in efflux activity of MDR1 in fibrotic skin. Bleomycin ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus
2 However, the skin level of MRI-1867, an MDR1 substrate, was dramatically lower in B6 mice (0.023 microM) than in Mdr1a/b-Bcrp KO mice (8.8 microM) due to a bleomycin-induced increase in efflux activity of MDR1 in fibrotic skin. Bleomycin ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus