Title : Propranolol inhibits the angiogenic capacity of hemangioma endothelia via blocking β-adrenoceptor in mast cell.

Pub. Date : 2021 Oct 14

PMID : 34650198






4 Functional Relationships(s)
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1 RESULTS: In propranolol-treated HMC-1s, the expressions of ADRB1 (beta1-AR) and ADRB2 (beta2-AR) were reduced by 70% and 60%, respectively, and that of cytokines and mediators were reduced. Propranolol adrenoceptor beta 2 Homo sapiens
2 However, propranolol can work well in shRNA-ADRB1 or shRNA-ADRB2 transfected HMC-1s. Propranolol adrenoceptor beta 2 Homo sapiens
3 CONCLUSIONS: Propranolol inhibit the proliferation of HemECs and promote their apoptosis and autophagy through acting on both beta1 and beta2 adrenoceptor in mast cell. Propranolol adrenoceptor beta 2 Homo sapiens
4 Propranolol can work well in shRNA-ADRB1 or shRNA-ADRB2 transfected HMC-1s. Propranolol adrenoceptor beta 2 Homo sapiens