Title : Peroxisome proliferator-activated receptor δ rescues xCT-deficient cells from ferroptosis by targeting peroxisomes.

Pub. Date : 2021 Nov

PMID : 34649350






1 Functional Relationships(s)
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1 GW501516-activated PPARdelta stabilized peroxisomes through catalase upregulation by targeting peroxisomal hydrogen peroxide-mediated lysosomal rupture, which led to ferroptosis of xCT-deficient MEFs. Hydrogen Peroxide catalase Mus musculus