Title : Host cells with transient overexpression of MDR1 as a novel in vitro model for evaluating on-target effect for activity against the epicellular Cryptosporidium parasite.

Pub. Date : 2021 Dec 24

PMID : 34648615






1 Functional Relationships(s)
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1 Transient overexpression of MDR1 increased drug tolerance of HCT-8 cells on paclitaxel, doxorubicin HCl and vincristine sulphate (2.11- to 2.27-fold increase), but not on cyclosporin A, daunorubicin HCl and nitazoxanide. Paclitaxel ATP binding cassette subfamily B member 1 Homo sapiens