Pub. Date : 2021 Nov 8
PMID : 34648034
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells. | Phenobarbital | stromal antigen 2 | Homo sapiens |
| 2 | STAG2 knockdown results in down-regulation of the luminal urothelial signature and up-regulation of the basal transcriptional program, mirroring differences between STAG2-high and STAG2-low human bladder tumors. | Phenobarbital | stromal antigen 2 | Homo sapiens |
| 3 | Our findings indicate that STAG2 participates in the DNA looping that keeps the basal transcriptional program silent and thus sustains the luminal program. | Phenobarbital | stromal antigen 2 | Homo sapiens |