Title : CRHCeA→VTA inputs inhibit the positive ensembles to induce negative effect of opiate withdrawal.

Pub. Date : 2021 Nov

PMID : 34642456






2 Functional Relationships(s)
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1 Here, we used neuronal activity-dependent labeling technique to characterize and temporarily control the VTA neuronal ensembles recruited by the initial morphine exposure (morphine-positive ensembles, Mor-Ens). Morphine opioid receptor mu 1 Homo sapiens
2 Electrophysiology and rabies viral tracing revealed the preferential connections between the VTA-projective corticotrophin-releasing hormone (CRH) neurons of central amygdala (CRHCeA VTA) and Mor-Ens, which was enhanced after escalating morphine exposure and mediated the negative effect during opiate withdrawal. Morphine opioid receptor mu 1 Homo sapiens