Title : The selective degradation of sirtuins via macroautophagy in the MPP+ model of Parkinson's disease is promoted by conserved oxidation sites.

Pub. Date : 2021 Oct 12

PMID : 34642296






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In neuronal Lund human mesencephalic (LUHMES) cells, all seven SIRTs were substrates for autophagy and showed an accelerated autophagy-dependent degradation upon 1-methyl-4-phenylpyridinium (MPP+) mediated oxidative insults in vitro, whereas the proteasome did not contribute to the removal of oxidized SIRTs. 1-Methyl-4-phenylpyridinium M-phase phosphoprotein 6 Homo sapiens