Title : Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes.

Pub. Date : 2021 Dec

PMID : 34624627






1 Functional Relationships(s)
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1 Extensive oxidation rates of BIBX1382 were observed in hepatocytes from humanized liver mice and were suppressed by the typical human AOX1 inhibitors raloxifene and hydralazine. Raloxifene Hydrochloride aldehyde oxidase 1 Homo sapiens