Title : A p.Arg127Gln variant in GPIbα LRR5 allosterically enhances affinity for VWF: a novel form of platelet-type VWD.

Pub. Date : 2022 Apr 12

PMID : 34619770






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 GoF GP1BA variants generate a high affinity conformation of the C-terminal disulfide loop with a consequent allosteric conformational change on another region of GPIbalpha, the leucine-rich-repeat (LRR) domain. Leucine glycoprotein Ib platelet subunit alpha Homo sapiens
2 GoF GP1BA variants generate a high affinity conformation of the C-terminal disulfide loop with a consequent allosteric conformational change on another region of GPIbalpha, the leucine-rich-repeat (LRR) domain. Leucine glycoprotein Ib platelet subunit alpha Homo sapiens