Pub. Date : 2022 Jan
PMID : 34619135
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic Exposure to Palmitic Acid Down-regulates AKT in Beta-Cells through Activation of mTOR. | Palmitic Acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Using palmitic acid (PA) in cultured beta-cells and islets, we demonstrated that chronic exposure to lipids leads to reduced viability and inhibition of cell cycle progression concurrent with downregulation of a pro-growth/survival kinase AKT, independent of glucose. | Palmitic Acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Using palmitic acid (PA) in cultured beta-cells and islets, we demonstrated that chronic exposure to lipids leads to reduced viability and inhibition of cell cycle progression concurrent with downregulation of a pro-growth/survival kinase AKT, independent of glucose. | Palmitic Acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | This AKT downregulation by PA is correlated with the induction of mTOR/S6K activity. | Palmitic Acid | AKT serine/threonine kinase 1 | Homo sapiens |