Title : Protective Effect of Xiao-Xu-Ming Decoction-Mediated Inhibition of ROS/NLRP3 Axis on Lipopolysaccharide-Induced Acute Lung Injury In Vitro and In Vivo.

Pub. Date : 2021

PMID : 34616481






2 Functional Relationships(s)
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1 Results: Our results showed that XXMD attenuated LPS-induced oxidative stress, barrier dysfunction, and the activation of NLRP3 inflammasome in vitro, as evidenced by enhanced ROS production, TEER levels, expression of NLRP3 and caspase 1 (p20) and release of IL-1beta and IL-18, and weakened cell permeability. Reactive Oxygen Species NLR family pyrin domain containing 3 Homo sapiens
2 Conclusion: The findings showed that XXMD could alleviate LPS-induced ALI injury and inhibit inflammation and suppress ROS/NLRP3 signaling pathway, which were involved in these protective effects. Reactive Oxygen Species NLR family pyrin domain containing 3 Homo sapiens