Pub. Date : 2021 Dec 1
PMID : 34614511
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin inhibits Wnt/beta-catenin pathway in uterine leiomyoma. | Simvastatin | Wnt family member 4 | Homo sapiens |
| 2 | The objective of this study is to examine the effects of simvastatin on the Wnt/beta-catenin signaling pathway in leiomyoma. | Simvastatin | Wnt family member 4 | Homo sapiens |
| 3 | The results of this study reveal that simvastatin significantly reduced the expression of Wnt4 and its co-receptor LRP5. | Simvastatin | Wnt family member 4 | Homo sapiens |
| 4 | Additionally, simvastatin reduced the expression of Wnt4 and total beta-catenin, as well as non-phosphorylated beta-catenin protein expression in response to estrogen and progesterone. | Simvastatin | Wnt family member 4 | Homo sapiens |
| 5 | Simvastatin also inhibited the expression of c-Myc, a downstream target of the Wnt/beta-catenin pathway. | Simvastatin | Wnt family member 4 | Homo sapiens |
| 6 | The effect of simvastatin on non-phosphorylated-beta-catenin, the key regulator of the Wnt/beta-catenin pathway, was recapitulated in human leiomyoma tissue. | Simvastatin | Wnt family member 4 | Homo sapiens |
| 7 | These results suggest that simvastatin may have a beneficial effect on uterine leiomyoma through suppressing the overactive Wnt/beta-catenin pathway. | Simvastatin | Wnt family member 4 | Homo sapiens |