Title : Inflammasome activation in infected macrophages drives COVID-19 pathology.

Pub. Date : 2022 Apr 1

PMID : 34611663






1 Functional Relationships(s)
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1 Although early IFN deficiency leads to enhanced disease, blocking either viral replication with Remdesivir or the downstream IFN stimulated cascade by injecting anti-IFNAR2 in vivo in the chronic stages of disease attenuates many aspects of the overactive immune-inflammatory response, especially the inflammatory macrophage response, and most consequentially, the chronic disease itself. remdesivir interferon alpha and beta receptor subunit 2 Homo sapiens