Title : Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1.

Pub. Date : 2021 Oct 11

PMID : 34610328






1 Functional Relationships(s)
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1 We discovered a leucine-derived monomethyl branched-chain fatty acid and its downstream metabolite, glycosphingolipid, which critically mediates the overall amino acid sensing by intestinal and neuronal mTORC1, which in turn regulates postembryonic development at least partly by controlling protein translation and ribosomal biogenesis. Leucine CREB regulated transcription coactivator 1 Mus musculus