Title : Inhibition of the long non-coding RNA ZFAS1 attenuates ferroptosis by sponging miR-150-5p and activates CCND2 against diabetic cardiomyopathy.

Pub. Date : 2021 Nov

PMID : 34609043






3 Functional Relationships(s)
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1 Ad-ZFAS1, Ad-sh-ZFAS1, mimic miR-150-5p, Ad-CCND2 and Ad-sh-CCND2 were intracoronarily administered to the mouse model or transfected into HG-treated cardiomyocytes to determine whether ZFAS1 regulates miR-150-5p and CCND2 in ferroptosis. mir-150-5p zinc finger, NFX1-type containing 1, antisense RNA 1 Mus musculus
2 ZFAS1 sponges miR-150-5p to downregulate CCND2 expression. mir-150-5p zinc finger, NFX1-type containing 1, antisense RNA 1 Mus musculus
3 However, transfection with Ad-ZFAS1 could reverse the positive effects of miR-150-5p mimic and Ad-CCND2 in vitro and in vivo. mir-150-5p zinc finger, NFX1-type containing 1, antisense RNA 1 Mus musculus