Pub. Date : 2021 Nov
PMID : 34606419
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cdc25C/cdc2/cyclin B, raf/MEK/ERK and PERK/eIF2alpha/CHOP pathways are involved in forskolin-induced growth inhibition of MM.1S cells by G2/M arrest and mitochondrion-dependent apoptosis. | Colforsin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Of note, we demonstrated that forskolin induced a decrease of p-C-Raf, p-MEK, p-ERK1/2 and p-p90Rsk, and an increase of p-PERK, p-eIF2alpha and CHOP, which indicated that the inhibition of Raf/MEK/ERK pathway and activation of PERK/eIF2alpha/CHOP pathway were involved, at least partially, in forskolin-induced MM.1S cells apoptosis. | Colforsin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Of note, we demonstrated that forskolin induced a decrease of p-C-Raf, p-MEK, p-ERK1/2 and p-p90Rsk, and an increase of p-PERK, p-eIF2alpha and CHOP, which indicated that the inhibition of Raf/MEK/ERK pathway and activation of PERK/eIF2alpha/CHOP pathway were involved, at least partially, in forskolin-induced MM.1S cells apoptosis. | Colforsin | mitogen-activated protein kinase 1 | Homo sapiens |