Title : Hydrogen Sulfide Attenuates Angiotensin II-Induced Cardiac Fibroblast Proliferation and Transverse Aortic Constriction-Induced Myocardial Fibrosis through Oxidative Stress Inhibition via Sirtuin 3.

Pub. Date : 2021

PMID : 34603602






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 NaHS inhibited cell proliferation and hydroxyproline secretion, decreased collagen I, collagen III, alpha-SMA, and DRP1 expression, alleviated oxidative stress, and improved mitochondrial respiration function and membrane potential in Ang II-stimulated cardiac fibroblasts, which were unavailable after SIRT3 was silenced. sodium bisulfide dynamin 1-like Mus musculus
2 In vivo, NaHS reduced hydroxyproline content, ameliorated perivascular and interstitial collagen deposition, and inhibited collagen I, collagen III, and DRP1 expression in the myocardium of WT mice but not SIRT3 KO mice with TAC. sodium bisulfide dynamin 1-like Mus musculus