Pub. Date : 2022 Mar
PMID : 34592243
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We performed genome-wide association studies (GWAS) on HDL3 cholesterol (after inverse normal transformation) and used the top variants associated with HLD3 cholesterol as instrumental variables (IVs) in the MR analysis. | Cholesterol | HDL3 | Homo sapiens |
| 2 | First, a logistic regression model showed that total HDL3 cholesterol (negatively) and phospholipids in very large HDL (positively) were associated with POAG. | Cholesterol | HDL3 | Homo sapiens |
| 3 | Further analyses using a Bayesian network analysis showed that only total HDL3 cholesterol was directly associated with POAG (OR = 0.72 per 1 standard deviation increase in HDL3 cholesterol; 95 % confidence interval (CI): 0.61, 0.84), independently of age, gender, IOP, BMI, education level, systolic blood pressure, axial length, and statin medication. | Cholesterol | HDL3 | Homo sapiens |
| 4 | Further analyses using a Bayesian network analysis showed that only total HDL3 cholesterol was directly associated with POAG (OR = 0.72 per 1 standard deviation increase in HDL3 cholesterol; 95 % confidence interval (CI): 0.61, 0.84), independently of age, gender, IOP, BMI, education level, systolic blood pressure, axial length, and statin medication. | Cholesterol | HDL3 | Homo sapiens |
| 5 | Using 4 IVs identified from the GWAS and with the inverse variance weighted MR method, we found that higher levels of HDL3 cholesterol was associated with a decreased odds of POAG (OR = 0.91, 95% CI: 0.84 - 0.98, P = 0.016). | Cholesterol | HDL3 | Homo sapiens |
| 6 | CONCLUSION: Overall, these results suggest that the relationship between HDL3 cholesterol and POAG might be causal and specific, and that dysregulation of cholesterol transport may thus play a role in the pathogenesis of POAG. | Cholesterol | HDL3 | Homo sapiens |
| 7 | CONCLUSION: Overall, these results suggest that the relationship between HDL3 cholesterol and POAG might be causal and specific, and that dysregulation of cholesterol transport may thus play a role in the pathogenesis of POAG. | Cholesterol | HDL3 | Homo sapiens |