Title : Kaempferol Blocks the Skin Fibroblastic Interleukin 1β Expression and Cytotoxicity Induced by 12-O-tetradecanoylphorbol-13-acetate by Suppressing c-Jun N-terminal Kinase.

Pub. Date : 2021 Sep 1

PMID : 34578957






3 Functional Relationships(s)
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1 TPA (5 muM) significantly induced cytotoxicity of NHDF, where a robust increase in the interleukin (IL)-1beta mRNA among the various pro-inflammatory cytokines. Tetradecanoylphorbol Acetate interleukin 1 alpha Homo sapiens
2 The skin fibroblastic cytotoxicity and IL-1beta expression induced by TPA were significantly ameliorated by a treatment with 100 nM of kaempferol. Tetradecanoylphorbol Acetate interleukin 1 alpha Homo sapiens
3 Interestingly, we found that kaempferol inhibited the phosphorylation of nuclear factor-kappa B (NF-kappaB) and the inhibitor NF-kappaB (IkappaBalpha), which are necessary for the expression of cleaved caspase-3 and the IL-1beta secretion in TPA-treated NHDF. Tetradecanoylphorbol Acetate interleukin 1 alpha Homo sapiens