Pub. Date : 2021 Sep 7
PMID : 34576795
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we isolated a yeast mutant with high levels of intracellular proline and found a missense mutation (Gln79His) on the PRO1 gene encoding the gamma-glutamyl kinase Pro1, a limiting enzyme in proline biosynthesis. | Proline | glutamate 5-kinase | Saccharomyces cerevisiae S288C |
| 2 | Here, we isolated a yeast mutant with high levels of intracellular proline and found a missense mutation (Gln79His) on the PRO1 gene encoding the gamma-glutamyl kinase Pro1, a limiting enzyme in proline biosynthesis. | Proline | glutamate 5-kinase | Saccharomyces cerevisiae S288C |
| 3 | Here, we isolated a yeast mutant with high levels of intracellular proline and found a missense mutation (Gln79His) on the PRO1 gene encoding the gamma-glutamyl kinase Pro1, a limiting enzyme in proline biosynthesis. | Proline | glutamate 5-kinase | Saccharomyces cerevisiae S288C |
| 4 | The amino acid change of Gln79 to His in Pro1 resulted in desensitization to the proline-mediated feedback inhibition of GK activity, leading to the accumulation of proline in cells. | Proline | glutamate 5-kinase | Saccharomyces cerevisiae S288C |
| 5 | The amino acid change of Gln79 to His in Pro1 resulted in desensitization to the proline-mediated feedback inhibition of GK activity, leading to the accumulation of proline in cells. | Proline | glutamate 5-kinase | Saccharomyces cerevisiae S288C |
| 6 | Biochemical and in silico analyses showed that the amino acid residue at position 79 is involved in the stabilization of the proline binding pocket in Pro1 via a hydrogen-bonding network, which plays an important role in feedback inhibition. | Proline | glutamate 5-kinase | Saccharomyces cerevisiae S288C |